Scientists attach barcodes to mouse embryos – human ones coming soon

Spanish scientists have attached silicon barcode labels to embryos and oocytes

Fans of the film Blade Runner may remember a scene in which the maker of an artificial snake is identified by a microscopic serial number on one of its scales. Well, in a rare case of present-day technology actually surpassing that predicted in a movie, we’ve now gone one better – bar codes on embryos. Scientists from Spain’s Universitat Autònoma de Barcelona (UAB), along with colleagues from the Spanish National Research Council, have successfully developed an identification system in which mouse embryos and oocytes (egg cells) are physically tagged with microscopic silicon bar code labels. They expect to try it out on human embryos and oocytes soon.

The purpose of the system is to streamline in vitro fertilization and embryo transfer procedures. If egg cells and embryos can be quickly and easily identified, then things should run much smoother, and success rates should be higher.

The labels, which had been declared biologically innocuous in an earlier study, are microinjected into the perivitelline space of mouse embryos – the perivitelline space is a region between the cell membrane and the zona pellucida, which is a cover that surrounds the embryo’s plasma membrane. The embryo exits the zona pellucida before entering the uterus, so the bar code would be shed at that point.

In the UAB lab studies, labeled embryos were shown to develop normally up until the blastocyst stage, which precedes implantation. The researchers also studied how well the labels stayed on throughout the development cycle, how easily they could be read with a standard microscope, how they could be eliminated after the shedding of the zona pellucida, and how well they could stand up to the freezing and thawing of their host embryo.

There were some problems with embryos being able to free themselves from the labels when they shed the zona pellucida. The scientists are therefore now looking at modifying the surface of the labels, so they could be mounted on the outside of the covering, instead of being injected into the perivitelline space. They are also working on an automated bar code reading system.

Permission has been given by the Government of Catalonia’s Department of Health for UAB to begin testing its system with human oocytes and embryos from several fertility clinics in Spain.

The research was recently published in the journal Human Reproduction.

Mount Everest 3G Base Station

3G networking reaches the top of the world

All of the TeliaSonera/Ncell 3G base stations in the Mount Everest region run on solar or solar hybrid power

Cream brought the country blues classic Sittin' on top of the world to an international audience in the late 1960s... and now you can watch it on YouTube while you're sitting there. Through its subsidiary Ncell, the Swedish telecommunications group TeliaSonera has launched 3G services in the Mount Everest area of Nepal – which makes the company the providers of the world's highest mobile data service.

The new 3G base station is located at an altitude of 5,200 meters (around 17,000 feet) and "will bring faster, more affordable telecommunication services to the people living in the Khumbu Valley, trekkers, and climbers alike," according to Lars Nyberg, President and CEO of TeliaSonera. The company has confirmed that those at the summit will be able to update their Facebook profile with a photo from the top of the world (although in such a deadly environment, you could be forgiven for having your mind on other things).

The first video call made over the network was to the highest base station on October 28, with speeds of up to 4-5Mbps being available. TeliaSonera also told Gizmag that there are now seven 3G base stations in the Everest region, all of which are either solar or solar hybrid powered. The company says that 14 cities in the area are also 3G-enabled, including Katmandu, Itahari, Bharatpur and Nepalgunj.

Although the company reports that mobile device use by locals is still relatively low, it is increasing and Ncell says that it will provide coverage for 90 per cent of the people of Nepal by the end of 2011.

Source:

Paul Riddden